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Cambridge Centre for Medical Materials

Department of Materials Science and Metallurgy

Studying at Cambridge

 

Dr. David Shepherd

Dr. David Shepherd

Post-Doctoral Research Associate


Office Phone: +44 (0)1223 334560

Biography:

David came to Cambridge in 2006 after completing a Physics degree at the University of Liverpool and has never really left. He attended the DESY (Deutsches Synchrotronen) summer school and spent his 4th year carrying out programming on a High Energy Physics project and I really missed the lab. He then succumbed to a Professor, at Liverpool, who drilled into them that biology was the future and biomaterials seemed a good stepping stone. His PhD was on the production and characterisation of a novel substituted hydroxyapatite, in his case zinc, and included physical, chemical and biological characterisation. This led to an Orthopaedics Research UK funded research fellowship focused on the use of zinc substituted hydroxyapatite as coating for implants using the plasma spraying technique. David has also worked with industry on characterising collagen fibres and currently work on an EU collaborative project looking at the biological response of human cells to polymeric materials.

Research Interests

David currently has two projects. His main project is working with European partners as part of Innovabone looking at the biological response, in vitro, of polymeric materials that will hopefully be used as a bone replacement material. He measures the response of human osteoblasts to the materials, in terms of the amount of alkaline phosphatase present and mineralization. David also uses human monocytes to measure the immunological response to the materials.

David’s other project is working with the British Antarctic Survey on comparing the shells of Antarctic species to temperate ones. To carry out this work he uses techniques such as Micro CT, SEM, TGA and XRD. It is leading to some interesting findings in terms of shell structure and shell repair mechanisms.

Topics

  • Calcium phosphates
  • Biomimetics
  • Tissue engineering
  • Immunulogical responses to biomaterials

Key Publications

  • J.H. SHEPHERD, D.V. SHEPHERD and S.M. BEST
    "Substituted Hydroxyapatites for Bone Repair", Journal of Materials Science: Materials in Medicine, 23(10), 2335-2347, (2012)
  • D. SHEPHERD and S. BEST
    "Production of Zinc Substituted Hydroxyapatite using precipitation routes", Biomedical Materials, 8,025003, (2013)
  • D. SHEPHERD, K. KAUPPINEN, N. RUSHTON, S. BEST and R. BROOKS
    "An in vitro study into the effect of zinc substituted hydroxyapatite on osteoclast number and activity", Journal of Biomedical Materials Research Part A, 102(11), 4136-4141, (2014)
  • D.V. SHEPHERD, J.H. SHEPHERD, S. GHOSE, S.J. KEW, R.E. CAMERON and S.M. BEST
    "The process of EDC-NHS cross-linking of reconstituted collagen fibres increases collagen fibrillar order and alignment", APL Materials, 3, 014902, (2015)