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Cambridge Centre for Medical Materials

Department of Materials Science and Metallurgy

Studying at Cambridge

 

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Scanning laser confocal microscope image of a collagen-fibrinogen freeze-dried scaffold.

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Figure: 3D micro-tomography images, demonstrating the differences in architecture achievable on variation of the thermal profile during freezing.

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The relationship between time at equilibrium and pore size appeared to be universal regardless of changes to the slurry, to the mould design, to the set freezing protocol or to the mould design. Inset: the slope of the curve was 1/n, where n = 4.8; fit with a linear regression curve ( p < 0.05, R2 = 0.8). (see publication *)

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Comparison of normal mammary tissue architecture (top) with organoid architecture of our in vitro model (bottom) showing immunofluorescence staining for lineage specific markers. Bars = 200 µm (leftmost panel) and 50 µm remainder.

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Recent Publications

J.H. SHEPHERD, D.HOWARD, A.K. WALLER, H.R. FOSTER, A. MUELLER, T. MOREAU, A.L. EVANS, M. ARUMUGAM, G. BOUËT CHALON, E. VRIEND, N. DAVIDENKO, C. GHEVAERT, S.M. BEST AND R.E. CAMERON “Structurally graduated collagen scaffolds applied to the ex vivo generation of platelets from human pluripotent stem cell-derived megakaryocytes: Enhancing production and purity”, Biomaterials182, 135 – 144 (2018) doi.org/10.1016/j.biomaterials.2018.08.019

R.D. HUME, S. PENSA, E.J. BROWN, P.A. KREUZALER, J. HITCHCOCK, A. HUSMANN, J.J. CAMPBELL, A.O. LLOYD-THOMAS, R.E. CAMERON AND C.J. WATSON “Tumour cell invasiveness and response to chemotherapeutics in adipocyte invested 3D engineered anisotropic collagen scaffolds”, Scientific Reports 8, 12658 (2018) doi.org/10.1038/s41598-018-30107-3

M. NAIR, A. HUSMANN, R E CAMERON and S BEST “In situ ESEM imaging of the vapor-pressure-dependent sublimation-induced morphology of ice”, Physical Review Materials 2, 2(4) (2018) 040401 doi: 10.1103/PhysRev Materials 2.040401